Analisis Bakteri Streptomyces griseus Sebagai Penghasil  Metabolit Sekunder

Sahla Sahira; Ulfa Auliah Dwiyanti. H.; Yusminah Hala

doi:10.33627/oz.v14i1.3193

Sahla Sahira Universitas Negeri Makassar
Ulfa Auliah Dwiyanti. H. Universitas Negeri Makassar
Yusminah Hala Universitas Negeri Makassar

DOI: https://doi.org/10.33627/oz.v14i1.3193

Keywords: Antibiotik, Metabolit sekunder, Streptomyces griseus

Abstract

Streptomyces griseus merupakan salah satu spesies bakteri dari genus Streptomyces yang dikenal sebagai penghasil utama metabolit sekunder, terutama antibiotik streptomisin. Studi pustaka ini bertujuan untuk menganalisis potensi Streptomyces griseus dalam menghasilkan senyawa bioaktif serta perannya dalam berbagai bidang, seperti kesehatan, industri farmasi, dan pertanian. Kajian ini dilakukan dengan mengumpulkan dan menganalisis berbagai literatur terkait karakteristik biologis, jalur biosintesis, serta faktor lingkungan yang mempengaruhi produksi metabolit sekunder oleh Streptomyces griseus Berdasarkan 5 tinjauan literatur, Streptomyces griseus memiliki kemampuan menghasilkan senyawa dengan aktivitas antibakteri, antioksidan, dan antikanker, yang telah diuji melalui berbagai penelitian sebelumnya. Produksi metabolit sekunder ini dipengaruhi oleh kondisi lingkungan seperti pH, suhu, ketersediaan nutrisi, dan regulasi genetik. Dengan pemahaman yang lebih dalam mengenai mekanisme biosintesis dan optimasi produksinya, Secara keseluruhan bakteri Sterptomyces griseus ini memiliki senyawa bioaktif yang berperan penting pada bidang farmasi maupun pertanian.

Downloads

Download data is not yet available.

References

Aftab, U., Zechel, D., & Sajid, I. (2015). Antitumor compounds from Streptomyces sp. KML-2, isolated from Khewra salt mines, Pakistan. Biological Research, 48. https://doi.org/10.1186/s40659-015-0046-3.

Alam, K., Mazumder, A., Sikdar, S., Zhao, Y., Hao, J., Song, C., Wang, Y., Sarkar, R., Islam, S., Zhang, Y., & Li, A. (2022). Streptomyces: The biofactory of secondary metabolites. Frontiers in Microbiology, 13. https://doi.org/10.3389/fmicb.2022.968053.

Caicedo Montoya, C., Manzo Ruiz, M., & Ríos-Estepa, R. (2021). Pan-Genome of the Genus Streptomyces and Prioritization of Biosynthetic Gene Clusters With Potential to Produce Antibiotic Compounds. Frontiers in Microbiology, 12. https://doi.org/10.3389/fmicb.2021.677558.

Cegielski, J., Chan, P., Chan, P., Lan, Z., Udwadia, Z., Viiklepp, P., Yim, J., & Menzies, D. (2020). Aminoglycosides and Capreomycin in the Treatment of Multidrug-resistant Tuberculosis: Individual Patient Data Meta-analysis of 12 030 Patients From 25 Countries, 2009-2016.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. https://doi.org/10.1093/cid/ciaa621.

Celladurai, R., & Vadamalai, S. (2022). Secondary Metabolites of Antagonistic Bacterial Strain Streptomyces griseus KD1 Exert Antibacterial and Anticacer Activity Against Breast Cancer MCF-7 Cells. Uttar Pradesh Journal Of Zoology. https://doi.org/10.56557/upjoz/2022/v43i243337.

Chater, K., Biró, S., Lee, K., Palmer, T., & Schrempf, H. (2010). The complex extracellular biology of Streptomyces.. FEMS microbiology reviews, 34 2, 171-98 https://doi.org/10.1111/j.1574-6976.2009.00206.x.

Danaei, M., Baghizadeh, A., Pourseyedi, S., Amini, J., & Yaghoobi, M. (2014). Biological control of plant fungal diseases using volatile substances of Streptomyces griseus. European Journal of Experimental Biology, 4.

Govindarajan, G., Yao, Z., Zhou, Z., Zheng, X., , J., Kumar, P., Ju, J., & Sun, C. (2023). Genome Sequencing of Streptomyces griseus SCSIO PteL053, the Producer of 2,2′-Bipyridine and Actinomycin Analogs, and Associated Biosynthetic Gene Cluster Analysis. Journal of Marine Science and Engineering. https://doi.org/10.3390/jmse11020396.

https://doi.org/10.1099/ijs.0.012419-0.

Hwang, S., Lee, N., Choe, D., Lee, Y., Kim, W., Kim, J., Kim, G., Kim, H., Ahn, N., Lee, B., Palsson, B., & Cho, B. (2022). System-Level Analysis of Transcriptional and Translational Regulatory Elements in Streptomyces griseus. Frontiers in Bioengineering and Biotechnology, 10. https://doi.org/10.3389/fbioe.2022.844200.

Jan, R., Asaf, S., Numan, M., , L., & Kim, K. (2021). Plant Secondary Metabolite Biosynthesis and Transcriptional Regulation in Response to Biotic and Abiotic Stress Conditions. Agronomy, 11, 968. https://doi.org/10.3390/AGRONOMY11050968.

Jiang, Z., Wei, J., Peng, N., & Li, Y. (2020). Aminoglycoside Antibiotics Inhibit Mycobacteriophage Infection. Antibiotics, 9. https://doi.org/10.3390/antibiotics9100714.

Kumar, D., Kumar, S., & Kumar, A. (2020). Extraction and characterization of secondary metabolites produced by bacteria isolated from industrial wastewater. Journal of water process engineering, 101811. https://doi.org/10.1016/j.jwpe.2020.101811.

Kumar, S., Korra, T., Thakur, R., Arutselvan, R., Kashyap, A., Nehela, Y., Chaplygin, V., Minkina, T., & Keswani, C. (2023). Role of Plant Secondary Metabolites in Defence and Transcriptional Regulation in Response to Biotic Stress. Plant Stress. https://doi.org/10.1016/j.stress.2023.100154.

Laidi, R., Kansoh, A., Elshafei, M., Cheikh, B., & Boumediene, H. (2006). Taxonomy, identification and biological activities of a novel isolate of Streptomyces tendae. .Laila, Z., Aima, Z., & Yunita, A. (2021). Analisis kemampuan pemecahan masalah matematis ditinjau dari minat belajar siswa. Jurnal Horizon Pendidikan, 1(3), 588-600.

Lara, C., A. et al. (2021). The GenomeAnalysis of the Human Lung-Associated Streptomyces sp. TR1341 Revealed the Presence of Beneficial Genes for Opportunistic Colonization of Human Tissues. Microorganisms. 9, 1547. 1-24.

Laxminarayan, R. (2022). The overlooked pandemic of antimicrobial resistance. Lancet 399, 606–607.

Lee, Y., Lee, N., Hwang, S., Kim, W., Jeong, Y., Cho, S., Palsson, B., & Cho, B. (2020). Genome-scale determination of 5´ and 3´ boundaries of RNA transcripts in Streptomyces genomes. Scientific Data, 7. https://doi.org/10.1038/s41597-020-00775-w.

Leertcanawanichakul & Sahabudden. (2023). Characterization of Streptomyces sp. KB1 and its cultural optimization for bioactive compounds production. 1-26.

Moradali, M., & Rehm, B. (2020). Bacterial biopolymers: from pathogenesis to advanced materials. Nature Reviews. Microbiology, 18, 195 - 210. https://doi.org/10.1038/s41579-019-0313-3.

Ohnishi, Y., Ishikawa, J., Hara, H., Suzuki, H., Ikenoya, M., Ikeda, H., Yamashita, A., Hattori, M., & Horinouchi, S. (2008). Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350. Journal of Bacteriology, 190, 4050 - 4060. https://doi.org/10.1128/JB.00204-08.

Ramarajan, M., Devilla, R., Dow, L., Walsh, N., Mead, O., Zakeel, M., Gallart, M., Richardson, A., & Thatcher, L. (2024). Genomic and Untargeted Metabolomic Analysis of Secondary Metabolites in the Streptomyces griseoaurantiacus Strain MH191 Shows Media-Based Dependency for the Production of Bioactive Compounds with Potential Antifungal Activity. Journal of Agricultural and Food Chemistry, 72, 24432 - 24448. https://doi.org/10.1021/acs.jafc.4c04989.

Rong, X., & Huang, Y. (2010). Taxonomic evaluation of the Streptomyces griseus clade using multilocus sequence analysis and DNA-DNA hybridization, with proposal to combine 29 species and three subspecies as 11 genomic species.. International journal of systematic and evolutionary microbiology, 60 Pt 3, 696-703 .

Sari, M. N., Kawuri, R., & Khalimi Khamdan. (2012). Streptomyces sp. Sebagai Biofungisida Patogen Fusarium oxysporum (Schlecht.) f.sp. lycopersici (Sacc.) Snyd. et Hans. Penyebab Penyakit Layu Pada Tanaman Tomat (Solanum lycopersicum L.). AGROTROP, 2(2), 161-169.

Sottorff, I., Wiese, J., Lipfert, M., Preußke, N., Sönnichsen, F., & Imhoff, J. (2019). Different Secondary Metabolite Profiles of Phylogenetically almost Identical Streptomyces griseus Strains Originating from Geographically Remote Locations. Microorganisms, 7. https://doi.org/10.3390/microorganisms7060166.

Venkova, T., Yeo, C., & Espinosa, M. (2018). Editorial: The Good, The Bad, and The Ugly: Multiple Roles of Bacteria in Human Life. Frontiers in Microbiology, 9. https://doi.org/10.3389/fmicb.2018.01702.

Vurukonda, S., Giovanardi, D., & Stefani, E. (2018). Plant Growth Promoting and Biocontrol Activity of Streptomyces spp. as Endophytes. International Journal of Molecular Sciences, 19. https://doi.org/10.3390/ijms19040952.

Waksman, S., Reilly, H., & Johnstone, D. (1946). Isolation of Streptomycin-producing Strains of Streptomyces griseus. Journal of Bacteriology, 52, 393 - 397. https://doi.org/10.1128/jb.52.3.393-397.1946.

Wang L., Ravichandran V., Yin Y., Yin J., Zhang Y. (2019). Produk alami dari mikrobiota usus mamalia. Trends Biotechnol. 37 492–504.

Wu, L., Chen, G., & Feng, G. (2017). Complete genome sequence of Streptomyces griseochromogenes ATCC 14511T, a producer of nucleoside compounds and diverse secondary metabolites. Journal of biotechnology, 249, 16-19 . https://doi.org/10.1016/j.jbiotec.2017.03.017.

Zaid, A., Aleissawy, A., Yahia, I., Yassien, M., Hassouna, N., & Aboshanab, K. (2021). Streptomyces griseus KJ623766: A Natural Producer of Two Anthracycline Cytotoxic Metabolites β- and γ-Rhodomycinone. Molecules, 26. https://doi.org/10.3390/molecules26134009.